Hydroxytyrosol and oleuropein from olive leaves: Potent anti-inflammatory and analgesic activities
作者： Zohra Marzouk , Belsem Marzouk , Abderrahman Bouraoui , Nadia Fenina , Ehsen Haloui
DOI:
关键词:
摘要: The goal of this study was to evaluate the analgesic and anti-inflammatory activities two polyphenols rich olive leaves extracts. At tested doses (100, 200 300 mg/kg), Oleuropein - Rich Olive Extract (ORE) Hydroxytyrosol (HRE) inhibited, significantly, writhing reduced carrageenan-induced hind paw edema in a dose dependent manner. HRE more effective than ORE relieve inflammation nociception. In addition, acute toxicity test showed that did not present up maximum 1000 mg/kg.
world-food.net 参考文章(65)
N. H. Aziz, S. E. Farag, L. A. A. Mousa, M. A. Abo-Zaid, Comparative antibacterial and antifungal effects of some phenolic compounds. Microbios. ,vol. 93, pp. 43- 54 ,(1998)
L Pieters, B van Poel, A Pieroni, D Heimler, A J Vlietinck, In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Die Pharmazie. ,vol. 51, pp. 765- 768 ,(1996)
Eddo Rugini, Massimo Mencuccini, Rita Biasi, Maria Maddalena Altamura, Olive (Olea europaea L.) In Protocol for Somatic Embryogenesis in Woody Plants, Vol. 77 (2005), pp. 345-360, doi:10.1007/1-4020-2985-3_27. ,vol. 77, pp. 345- 360 ,(2005) , 10.1007/1-4020-2985-3_27
Raffaella Briante, Maurizio Patumi, Stefano Terenziani, Ettore Bismuto, Ferdinando Febbraio, Roberto Nucci, Olea europaea L. Leaf Extract and Derivatives: Antioxidant Properties Journal of Agricultural and Food Chemistry. ,vol. 50, pp. 4934- 4940 ,(2002) , 10.1021/JF025540P
Olumayokun A Olajide, J.Modupe Makinde, S.Olubusayo Awe, Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. Journal of Ethnopharmacology. ,vol. 66, pp. 113- 117 ,(1999) , 10.1016/S0378-8741(99)00006-9
Giuseppe Bisignano, Antonio Tomaino, Rossella Lo Cascio, Giuseppe Crisafi, Nicola Uccella, Antonella Saija, On the In‐vitro Antimicrobial Activity of Oleuropein and Hydroxytyrosol Journal of Pharmacy and Pharmacology. ,vol. 51, pp. 971- 974 ,(2010) , 10.1211/0022357991773258
C. A. Winter, E. A. Risley, G. W. Nuss, Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs Experimental Biology and Medicine. ,vol. 111, pp. 544- 547 ,(1962) , 10.3181/00379727-111-27849
Hedya Jemai, Mohamed Bouaziz, Ines Fki, Abdelfattah El Feki, Sami Sayadi, Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves Chemico-Biological Interactions. ,vol. 176, pp. 88- 98 ,(2008) , 10.1016/J.CBI.2008.08.014
Nikolaos K. Andrikopoulos, Andriana C. Kaliora, Andreana N. Assimopoulou, Vassilios P. Papageorgiou, Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. Journal of Medicinal Food. ,vol. 5, pp. 1- 7 ,(2002) , 10.1089/109662002753723160
Elizabeth A. Miles, Pinelope Zoubouli, Philip C. Calder, Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures Nutrition. ,vol. 21, pp. 389- 394 ,(2005) , 10.1016/J.NUT.2004.06.031