Rapamycin suppresses Aβ25-35- or LPS-induced neuronal inflammation via modulation of NF-κB signaling.
作者： Ying-Chun Liu , Xiao-Xiao Gao , Ling Chen , Xiao-qing You
DOI: 10.1016/J.NEUROSCIENCE.2017.05.005
关键词:
摘要: Rapamycin (RAPA), an inhibitor of mammalian target rapamycin (mTOR), exhibits a high neuroprotective action against neurodegenerative diseases in mouse models. Since neuroinflammation has been shown to be involved Alzheimer's disease (AD) development and progression, the aim this study was examine anti-inflammatory role RAPA AD vivo vitro, investigate underlying mechanisms. We found that amyloid-β (Aβ) induced neuronal inflammation remarkable increase mTOR activity in-vivo in-vitro models inflammation, suggesting critical signaling inflammation. In addition, administration down-regulate mTOR, p-mTOR, Nuclear factor kappa B (NF-κB) p65, p-p65, TNF-α, IL-1β Bax protein expression Aβ25-35- or lipopolysaccharides (LPS)-treated mice cultured Neuro-2a (N2a) cells. Moreover, disrupted Aβ25-35-induced nuclear translocation NF-κB. Our findings indicate inhibits LPS-induced through suppressing reducing import
sci-hub.se 参考文章(42)
Yoshiyuki Morishima, Yukiko Gotoh, Janine Zieg, Tamera Barrett, Hiromichi Takano, Richard Flavell, Roger J. Davis, Yasufumi Shirasaki, Michael E. Greenberg, β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand The Journal of Neuroscience. ,vol. 21, pp. 7551- 7560 ,(2001) , 10.1523/JNEUROSCI.21-19-07551.2001
Hemachander Capiralla, Valérie Vingtdeux, Haitian Zhao, Roman Sankowski, Yousef Al-Abed, Peter Davies, Philippe Marambaud, Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade Journal of Neurochemistry. ,vol. 120, pp. 461- 472 ,(2012) , 10.1111/J.1471-4159.2011.07594.X
Huayan Liu, Jinyan Wang, Jun Wang, Ping Wang, Yixue Xue, Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways. Brain Research. ,vol. 1618, pp. 149- 158 ,(2015) , 10.1016/J.BRAINRES.2015.05.035
Ruishan Wang, Shaoya Chen, Yingchun Liu, Shiyong Diao, Yueqiang Xue, Xiaoqing You, Edwards A. Park, Francesca-Fang Liao, All-trans-retinoic Acid Reduces BACE1 Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling * Journal of Biological Chemistry. ,vol. 290, pp. 22532- 22542 ,(2015) , 10.1074/JBC.M115.662908
Charleine Zussy, Anthony Brureau, Emeline Keller, Stéphane Marchal, Claire Blayo, Brice Delair, Guy Ixart, Tangui Maurice, Laurent Givalois, Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0053117
Christian Haass, Dennis J. Selkoe, Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide Nature Reviews Molecular Cell Biology. ,vol. 8, pp. 101- 112 ,(2007) , 10.1038/NRM2101
S. Inoue, H. Nakase, M. Matsuura, S. Mikami, S. Ueno, N. Uza, T. Chiba, The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease. Clinical and Experimental Immunology. ,vol. 156, pp. 172- 182 ,(2009) , 10.1111/J.1365-2249.2008.03872.X
A. Kezic, J.U. Becker, F. Thaiss, The effect of mTOR-inhibition on NF-κB activity in kidney ischemia-reperfusion injury in mice. Transplantation proceedings. ,vol. 45, pp. 1708- 1714 ,(2013) , 10.1016/J.TRANSPROCEED.2013.02.110
S. Erlich, A. Alexandrovich, E. Shohami, R. Pinkas-Kramarski, Rapamycin is a neuroprotective treatment for traumatic brain injury Neurobiology of Disease. ,vol. 26, pp. 86- 93 ,(2007) , 10.1016/J.NBD.2006.12.003
Yunshuang Yue, Yi Wang, Dan Li, Zhigang Song, Hongchao Jiao, Hai Lin, A central role for the mammalian target of rapamycin in LPS-induced anorexia in mice Journal of Endocrinology. ,vol. 224, pp. 37- 47 ,(2015) , 10.1530/JOE-14-0523