Major histocompatibility complex class I binding predictions as a tool in epitope discovery.

摘要: SummaryOver the last decade, in silico models of major histocompatibilitycomplex (MHC) class I pathway have developed significantly. Before, pep-tide binding could only be reliably modelled for a few human ormouse histocompatibility molecules; now, high-accuracy predictions areavailable any leucocyte antigen (HLA) -A or -B molecule withknown protein sequence. Furthermore, peptide to MHC mole-cules from several non-human primates, mouse strains and other mam-mals can now predicted. In this review, number differentprediction methods are briefly explained, highlighting most useful andhistorically important. Selected case stories, where these ‘reverse immu-nology’ systems been used actual epitope discovery, brieflyreviewed. We conclude that new generation discovery sys-tems has become highly efficient tool recom-mend less accurate prediction past abandoned,as obsolete.Keywords: cytotoxic T lymphocytes; prediction; leucocyteantigen; complex I; histocompatibilitycomplex–peptide