Aberrant NEAT1 expression is associated with clinical outcome in high grade glioma patients

摘要: Long noncoding RNA (lncRNA) NEAT1 has been reported to play critical roles in various human tumor entities and related the survival of patients with malignancies. However, little is known about role lncRNA glioma patients. The aim this study was investigate expression its correlation clinicopathological features prognosis glioma; we analyzed relationship characteristics In our results, relative level higher cancer tissues compared adjacent noncancerous (p < 0.001). High observed be closely correlated larger size = 0.023), WHO grade 0.005), recurrence 0.011). Kaplan-Meier curves showed that high unfavorable overall (OS) than low group 0.002). Multivariate analysis results revealed overexpression an independent prognostic factor for OS addition postoperative chemoradiotherapy grade. Moreover, stage III~IV disease conferred (stage p 0.002, 0.000). This supports as a potential predictor association carcinogenesis progression glioma.