Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: a population-based study in Ontario, Canada.
作者： Lawrence F Paszat , William J Mackillop , Patti A Groome , Karleen Schulze , Eric Holowaty
DOI: 10.1016/S0360-3016(98)00412-X
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摘要: Abstract Purpose: To compare the risk of mortality from myocardial infarction (MI) after left-sided postlumpectomy radiotherapy (RT) to right-sided RT. Methods: We conducted a population-based cohort study cases invasive female breast cancer in Ontario, diagnosed between January 1, 1982 and December 31, 1987 ( n = 25,570). Records Ontario Cancer Registry (OCR) were linked hospital procedure discharge abstracts RT records centers. A case was labelled as lumpectomy if this maximum surgery within 4 months diagnosis. Postlumpectomy occurred up 1 year postdiagnosis. Laterality assigned laterality descriptor records. having had fatal MI ICD code 410 (myocardial infarction) recorded cause death OCR. used logistic regression likelihood utilization : 1. Dose per fraction > 2.00 Gy; 2. cobalt vs. linac; 3. boost life table analysis log rank test comparing time diagnosis women who received right-sided. Cox proportional hazards models relative for overall, stratified by age, characteristics, among conditional survival cohorts. Results: 1,555 1,451 cases. With follow-up 1995, 2% with compared 1% Comparison failure showed group be associated higher p 0.02). Adjusting age at diagnosis, 2.10 (1.11, 3.95). Conclusion: Among 1982–1987,
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