Contemporary Breast Radiotherapy and Cardiac Toxicity.

摘要: Long-term cardiac effects are an important component of survivorship after breast radiotherapy. The pathophysiology cardiotoxicity, history radiotherapy, current methods avoidance, modern outcomes, context historical quantifying effects, and future directions reviewed in this article. Radiation-induced oxidative stress induces proinflammatory cytokines is a process that potentiates late fibrosis intimal proliferation endothelial vasculature. Breast radiation therapy has changed substantially recent decades. Several technologies exist to improve avoidance such as deep inspiration breath hold, gating, accelerated partial irradiation, use 3-dimensional planning. Modern outcomes may vary notably from long-term given the differences dose with techniques. Methods radiation-related cardiotoxicity correlate risks needed data exploring techniques measuring computed tomography coronary artery calcium score, single-photon emission imaging, biomarkers. Placing data, dosimetric correlations, relative risk key when weighing benefits radiotherapy cancer control survival. Estimating present day treatment era includes challenges length follow-up confounding cardiotoxic agents evolving systemic chemotherapy targeted therapies. Future both multidisciplinary management advancing technology oncology provide further improvements patient reduction survivorship.