Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
作者： Fei Ge , Wenlin Chen , Junying Qin , Zhongmei Zhou , Rong Liu
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摘要: The Kruppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis. KLF5 protein degradation is increased by several E3 ubiquitin ligases, including WWP1 SCFFbw7, through the ubiquitin-proteasome pathway. However, deubiquitinase (DUB) of not demonstrated. In this study, we identified ATXN3L as a DUB genome-wide siRNA screening. directly binds KLF5, decreasing its ubiquitination thus degradation. Functionally, knockdown inhibits cancer proliferation partially KLF5. These findings reveal previously unrecognized role in regulation stability cancer. might be therapeutic target for
impactjournals.com参考文章(26)
Zhongmei Zhou, Ceshi Chen, Nanshan Chang, Wenlin Chen, Jing Tan, Tianning Zou, Rong Liu, Guosheng Ren, Runxiang Yang, Fei Ge, WWOX suppresses KLF5 expression and breast cancer cell growth Chinese Journal of Cancer Research. ,vol. 26, pp. 511- 516 ,(2014) , 10.3978/J.ISSN.1000-9604.2014.09.03
Keith D. Wilkinson, Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. The FASEB Journal. ,vol. 11, pp. 1245- 1256 ,(1997) , 10.1096/FASEBJ.11.14.9409543
Ke-Wen Zhao, Deepa Sikriwal, Xueyuan Dong, Peng Guo, Xiaodong Sun, Jin-Tang Dong, Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells Biochemical Journal. ,vol. 437, pp. 323- 333 ,(2011) , 10.1042/BJ20101388
Bernat Crosas, Deubiquitinating Enzyme Inhibitors and their Potential in Cancer Therapy Current Cancer Drug Targets. ,vol. 14, pp. 506- 516 ,(2014) , 10.2174/1568009614666140725090620
M. He, M. Han, B. Zheng, Y.-N. Shu, J.-K. Wen, Angiotensin II Stimulates KLF5 Phosphorylation and its Interaction with c-Jun Leading to Suppression of p21 Expression in Vascular Smooth Muscle Cells Journal of Biochemistry. ,vol. 146, pp. 683- 691 ,(2009) , 10.1093/JB/MVP115
Jin-Tang Dong, Ceshi Chen, Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cellular and Molecular Life Sciences. ,vol. 66, pp. 2691- 2706 ,(2009) , 10.1007/S00018-009-0045-Z
Jianming Jiang, Yun-Shen Chan, Yuin-Han Loh, Jun Cai, Guo-Qing Tong, Ching-Aeng Lim, Paul Robson, Sheng Zhong, Huck-Hui Ng, A core Klf circuitry regulates self-renewal of embryonic stem cells Nature Cell Biology. ,vol. 10, pp. 353- 360 ,(2008) , 10.1038/NCB1698
Houjun Xia, Chunyan Wang, Wenlin Chen, Hailin Zhang, Leena Chaudhury, Zhongmei Zhou, Rong Liu, Ceshi Chen, Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer Journal of Biological Chemistry. ,vol. 288, pp. 26731- 26740 ,(2013) , 10.1074/JBC.M113.483958
Takahiro Seki, Lijie Gong, Aislinn J. Williams, Norio Sakai, Sokol V. Todi, Henry L. Paulson, JosD1, a Membrane-targeted Deubiquitinating Enzyme, Is Activated by Ubiquitination and Regulates Membrane Dynamics, Cell Motility, and Endocytosis * Journal of Biological Chemistry. ,vol. 288, pp. 17145- 17155 ,(2013) , 10.1074/JBC.M113.463406
Edgardo Rodríguez-Lebrón, Maria doCarmo Costa, Katiuska Luna-Cancalon, Therese M Peron, Svetlana Fischer, Ryan L Boudreau, Beverly L Davidson, Henry L Paulson, Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice. Molecular Therapy. ,vol. 21, pp. 1909- 1918 ,(2013) , 10.1038/MT.2013.152