Molecularly targeted drugs for the treatment of cancer: oral complications and pathophysiology.

摘要: Background Targeted cancer therapy is a new approach for the treatment of cancer. It involves specific molecular target, mainly receptor that serves as target monoclonal antibodies or tyrosine kinase inhibitors. Side-effects these regimens are described to be mild, compared those classical chemotherapy. There lack in documentation and understanding oral complications related molecularly targeted drugs. Methods In this review, we tried make systematic review databases Pubmed Scopus, using "targeted therapy" "oral", "mucositis", "stomatitis", "bleeding", "hemorrhage" search terms. Specific drug name searches were not conducted. The yielded 97 results. Only articles EGFR VEGFR inhibition selected. Finally 13 met criteria. RESULTS discussed possible pathogenetic mechanisms presented. Results appears most serious side-effect mucositis/stomatitis may affect whole gastrointestinal tract. rarely results discontinuation. Reduced saliva secretion, xerostomia dysphagia can severe with some interfere food uptake. Osteonecrosis, wound healing impairment, spontaneous gingival bleeding dysgeusia also reported. Conclusions Considering data it obvious symptoms should considered context holistic management patients. Oral ignored but recorded during physical examination, because they significantly impair daily activities patients' quality life.