Lewisy Promotes Migration of Oral Cancer Cells by Glycosylation of Epidermal Growth Factor Receptor

摘要: Aberrant glycosylation changes normal cellular functions and represents a specific hallmark of cancer. Lewisy (Ley) carbohydrate upregulation has been reported in variety cancers, including oral squamous cell carcinoma (OSCC). A high level Ley expression is related to poor prognosis patients with However, it unclear how mediates cancer progression. In this study, the role OSCC was explored. Our data showed that upregulated HSC-3 OC-2 lines. Particularly, epidermal growth factor receptor (EGFR) found cells, modification absent upon inhibition synthesis. The absence EGFR weakened phosphorylation AKT ERK response (EGF). Additionally, EGF-triggered migration reduced, but proliferation not affected. stabilized ligand activation. Conversely, accelerated degradation. summary, these results indicate increased cells able promote by modifying which turn stabilizes downstream signaling. Targeting on could have potential therapeutic effect