Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain
作者： K Etou , T Kuroki , Y Tatebayashi , N Tashiro , M Hirano
DOI: 10.1016/0006-2952(95)02127-2
关键词:
摘要: To elucidate the psychotropic actions of calcium (Ca) antagonists, we investigated effect voltage-dependent Ca channel nifedipine and flunarizine, on phencyclidine (PCP)-induced changes in monoamine metabolism regional brain areas rats. The results indicate that administration alone attenuated dopamine (DA) nucleus caudatus putamen while enhancing serotonin (5-HT) metabolism. By contrast, flunarizine increased DA PCP significantly metabolite levels prefrontal cortex, putamen, amygdala. PCP-induced increases these regions were antagonized by nifedipine, but not flunarizine. These attenuates hyperactivity dopaminergic neurons, suggesting antipsychotic properties for this drug.
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sci-hub.se 参考文章(16)
Luca Pani, Alexander Kuzmin, Marco Diana, Graziella De Montis, Gian Luigi Gessa, Zvani Luigi Rossetti, Calcium receptor antagonists modify cocaine effects in the central nervous system differently European Journal of Pharmacology. ,vol. 190, pp. 217- 221 ,(1990) , 10.1016/0014-2999(90)94128-K
Jack A. Grebb, Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice Life Sciences. ,vol. 38, pp. 2375- 2381 ,(1986) , 10.1016/0024-3205(86)90605-3
Paul J. Marangos, Jitendra Patel, Charles Miller, Andrea M. Martino, Specific calcium antagonist binding sites in brain. Life Sciences. ,vol. 31, pp. 1575- 1585 ,(1982) , 10.1016/0024-3205(82)90049-2
T. Kuroki, Y. Tatebayashi, K. Ide, Y. Yonezawa, T. Tsutsumi, T. Matsumoto, M. Hirano, H. Uchimura, Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain Neuropeptides. ,vol. 21, pp. 167- 173 ,(1992) , 10.1016/0143-4179(92)90041-T
Remi Quirion, Candace B. Pert, Certain calcium antagonists are potent displacers of [3H]phencyclidine (PCP) binding in rat brain. European Journal of Pharmacology. ,vol. 83, pp. 155- 156 ,(1982) , 10.1016/0014-2999(82)90305-3
Renato Gaggi, Anna Maria Gianni, Effects of calcium antagonists on biogenic amines in discrete brain areas. European Journal of Pharmacology. ,vol. 181, pp. 187- 197 ,(1990) , 10.1016/0014-2999(90)90078-K
Olgierd Pucilowski, Psychopharmacological properties of calcium channel inhibitors. Psychopharmacology. ,vol. 109, pp. 12- 29 ,(1992) , 10.1007/BF02245476
Gabriel de Erausquin, Gary Brooker, Ingeborg Hanbauer, K+-evoked dopamine release depends on a cytosolic Ca2+ pool regulated by N-type Ca2+ channels Neuroscience Letters. ,vol. 145, pp. 121- 125 ,(1992) , 10.1016/0304-3940(92)90001-N
Jan Tytgat, Petrus J. Pauwels, Johan Vereecke, Edward Carmeliet, Flunarizine inhibits a high-threshold inactivating calcium channel (N-type) in isolated hippocampal neurons. Brain Research. ,vol. 549, pp. 112- 117 ,(1991) , 10.1016/0006-8993(91)90606-V
F. Fadda, G. L. Gessa, E. Mosca, E. Stefanini, Different effects of the calcium antagonists nimodipine and flunarizine on dopamine metabolism in the rat brain. Journal of Neural Transmission. ,vol. 75, pp. 195- 200 ,(1989) , 10.1007/BF01258630