Identification of Novel Epigenetic Markers for Clear Cell Renal Cell Carcinoma
作者： Gul S. Dalgin , Michele Drever , Tara Williams , Thomas King , Charles DeLisi
DOI: 10.1016/J.JURO.2008.04.137
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摘要: Purpose: We identified significantly hypermethylated genes in clear cell renal carcinoma.Materials and Methods: previously a set of under expressed carcinoma tissue through transcriptional profiling robust computational screen. selected 19 these for hypermethylation analysis using rigorous search the best candidate regions, considering CpG islands transcription factor binding sites. The were analyzed DNA 38 matched normal samples matrix assisted laser desorption ionization time-of-flight mass spectrometry. significance was assessed 3 statistical tests. validated down-regulation at RNA protein levels separate patients reverse transcriptase-polymerase chain reaction, immunohistochemistry Western blots.Results: found 7 regions f...
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