The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment.

摘要: Inflammatory mediators and inflammatory cells in the microenvironment promote transformation of normal to cancer early stage cancer, growth development cells, induce tumor immune escape. The monomeric active ingredient β-elemene is extracted from traditional Chinese medicine Curcuma wenyujin has been proven have good anti-inflammatory antitumor activities clinical applications for more than 20 years China. Recent studies found that this plays a vital role macrophage infiltration M2 polarization, as well regulating disorders, it even regulates transcription factors NF-κB STAT3 alter inflammation, tumorigenesis, development. In addition, not only different (such TNF-α, IFN, TGF-β, IL-6/10) but also oxidative stress vivo vitro. excellent effects its ability tumors gradually elaborated. Although study ingredients medicines insufficient terms quality quantity, pharmacological will be revealed after β-elemene.