Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling

摘要: Cellular communication via intracellular signalling pathways is crucial. Expression and activation of proteins heterogenous between isogenic cells the same cell-type. However, mechanisms evolved to enable sufficient ensure cellular functions. We use information theory clarify facilitating IL-6-induced JAK/STAT despite cell-to-cell variability. show that different enabling robustness against variability complement each other. Early STAT3 robust as long cytokine concentrations are low. Robustness at high ensured by expression or serine phosphorylation. Later feedback-inhibitor SOCS3 increases robustness. Channel Capacity limited in affected governing Increasing amount robustness, whereas increasing tyrosine phosphorylation reduces but Capacity. In summary, we elucidate preventing dysregulated reliable heterogeneity.