Swelling-activated organic osmolyte efflux: A new role for anion channels

摘要: Efflux of intracellular electrolytes and small organic solutes termed osmolytes is a universal response to cell swelling. While volume-activated ion efflux pathways have been studied extensively, relatively little was known until recently about the mechanisms regulation osmolyte release. An accumulating body evidence, however, now indicates that structurally dissimilar are lost from cells via swelling-activated anion channel. We this channel VSOAC for volume-sensitive osmolyte-anion The purpose review summarize our current understanding process volume regulatory efflux.