In utero infection and adult schizophrenia.

摘要: We review emerging evidence indicating that in utero exposure to infection is a risk factor for schizophrenia. It hypothesized prenatal increases the liability schizophrenia adulthood by adversely affecting maturation of critical brain structural and functional components implicated pathogenesis pathophysiology disorder. Early role includes investigations linking with birth during winter urban regions, ecologic studies demonstrating associations between influenza epidemics births pre-schizophrenic patients. The findings latter are, however, equivocal. To more rigorously address this question, our group has used increasingly sophisticated research designs incorporate refined measures outcome, continuous follow-up treated cases. This work already yielded several intriguing findings, including two infections--rubella respiratory infection. also describe ongoing cohort are expected advance further, utilize maternal serum samples drawn pregnancy offspring who were later diagnosed