Organ transplantation and osteoporosis

摘要: Organ transplantation offers new life to patients who suffer from incurable disease. The problem of rejection the transplanted organ has been overcome with use potent immunosuppressive drugs. These drugs, although they allow graft tolerance and survival, also are associated complications such as osteoporosis. Although factors nutrition, gonadal status, ambulatory status important, drugs appears be main factor in development that responsible for this bone loss glucocorticoids calcineurin phosphatase inhibitors, cyclosporine tacrolimus. incidence disease depends, part, on which is transplanted. Kidney transplant recipients appear less susceptible overt osteoporosis than do heart or liver recipients. most critical period within first 6 months, dramatic reduction occurring 3 months following transplantation. Trabecular (cancellous) spine at risk, vertebral fractures commonly. Transplant should evaluated by mineral densitometry measurement vitamin D metabolites, blood urea nitrogen, creatinine, calcium, phosphate. Markers turnover may help assessing rate remodeling. Gonadal function ascertained serum testosterone (males) estradiol (females) levels. Therapy directed toward prevention well helping restore what already have lost. Administration calcium sex hormone replacement, if indicated, considered.(ABSTRACT TRUNCATED AT 250 WORDS)