Targeting Multidrug Resistance Protein 1 (MRP1,ABCC1): Past, Present, and Future
作者： Susan P.C. Cole
DOI: 10.1146/ANNUREV-PHARMTOX-011613-135959
关键词:
摘要: The human ATP-binding cassette transporter multidrug resistance protein 1 (MRP1), encoded by ABCC1, was initially identified because of its ability to confer in lung cancer cells. It is now established that MRP1 plays a role protecting certain tissues from xenobiotic insults and it mediates the cellular efflux proinflammatory cysteinyl leukotriene C4 as well vast array other endo- organic anions. Many these are glutathione (GSH) or glucuronide conjugates, products Phase II drug metabolism. also reduced oxidized forms GSH thus contributes many physiological pathophysiological processes influenced small peptides, including oxidative stress. In this review, pharmacological aspects considered context current status future prospects genetic modulation activity.
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