Increased osteoblast density in the presence of novel calcium phosphate coated magnetic nanoparticles.
作者： Rajesh A Pareta , Eric Taylor , Thomas J Webster
DOI: 10.1088/0957-4484/19/26/265101
关键词:
摘要: Bone diseases (including osteoporosis, osteoarthritis and bone cancer) are of great concern to the medical world. Drugs available treat such diseases, but often these drugs not specifically targeted site disease and, thus, lack an immediate directed therapeutic effect. The optimal drug delivery system should enhance healthy growth with high specificity disease. It has been previously shown that magnetic nanoparticles can be in presence a field any part body, allowing for site-specific possibly increase density. objective present study was build off this evidence determine density osteoblasts (bone forming cells) various uncoated coated could eventually used applications. Results showed some (specifically, γ-Fe(2)O(3)) significantly promoted osteoblast (that is, cells per well) after 5 8 days culture compared controls (no particles). These were further calcium phosphate (CaP; main inorganic component bone) tailor them treating diseases. coatings conducted either bovine serum albumin (BSA) or citric acid (CA) reduce nanoparticle agglomeration, common problem resulting from use which decreases their effectiveness. nanoparticles, (γ-Fe(2)O(3)), BSA increased 1 day. In manner, provided unexpected CaP-coated γ-Fe(2)O(3) (compared no particles) studied numerous
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