Conditioned taste aversions: Vagal and circulatory mediation of the toxic unconditioned stimulus

摘要: In these experiments we tested the hypothesis that same afferent systems which mediate vomiting reflexes also participate in conditioned taste aversions are formed when ingestion of a cue is paired with subsequent internal malaise. Borison and Wang have shown emetic dogs cats integrated brainstem center responds to local gastric irritation mediated by vagus or bloodborne toxins monitored brain stem chemoreceptors. This system may taste-illness conditioning since anatomically associated relay nucleus for primary afferents. We subdiaphragmatic vagotomy rats disrupts acquisition saccharin aversion induced repeated trials low doses intragastric intraperitoneal copper sulfate. contrast, there little effect on produced single, larger dose sulfate injected directly into blood via tail vein, although vagotomized displayed an accelerated extinction pattern. These results parallel reports suggest functional relationship between acute eject poison chronic inhibit poison; further, they provide evidence responses subserved, at least part, similar neural mechanisms.