Universality of parabrachial mediation of conditioned taste aversion

摘要: Abstract Disruption of conditioned taste aversion (CTA) by tetrodotoxin (TTX) blockade parabrachial nuclei elicited after ingestion the gustatory CS and before administration visceral US is revealed unchanged preference in retrieval test performed two days acquisition. The universality above amnesia was examined rats. In Experiment 1, TTX disrupted CTAs when sodium saccharin (0.1%), quinine hydrochloride (0.0072%), chloride (0.9%) or a garlic extract were used as i.p. LiCl (0.15 M, 2% body weight) US. 2, 0.9% NaCl injection weight), D-amphetamine (3 mg/kg) carbachol served 3 showed that post-drinking blocked also CTA induced drinking, i.e. under conditions CS—US identity. Experiments 4 5 demonstrated not confounded TTX-induced reduction fluid intake because disruption well expressed even tested recovery normal animals receiving 12 preacquisition adaptation to limited access. It concluded represent an important point convergence for various classes eliciting stimuli.