Transcutaneous high-frequency alternating current for rapid reversible muscle force reduction below pain threshold.

摘要: OBJECTIVE The development of non-invasive, quickly reversible techniques for controlling undesired muscle force production (e.g. spasticity) could expand rehabilitation approaches in those with pathology by increasing the type and intensity exercises that can be performed. High-frequency alternating current (HFAC) has been previously established as a viable method blocking neural conduction peripheral nerves. However, clinical application HFAC nerve block is limited due to invasiveness surgical procedures painful onset response. This study aimed examine use transcutaneous (tHFAC) at various stimulation frequencies address these shortfalls. APPROACH Ten individuals participated study. Surface electrodes were utilized apply tHFAC (0.5-12 kHz) median ulnar Individual pain threshold was determined gradual increase amplitude. Subjects then performed force-matching task producing grip forces up maximal voluntary contraction level without below threshold. MAIN RESULTS Pain amplitude increased linearly frequency. Statistical analysis showed both frequency charge injected per phase had significant effects (p   <  0.05) on reduction. At group level, reduced maximum 40.7%  ±  8.1%. Baseline trials interspersed between consistent force, indicating fatigue not factor SIGNIFICANCE Our results demonstrate effectiveness reducing when applied threshold, suggesting its potential viability. Future studies are necessary further elucidate mechanism reduction before application.