Hepatic Injury in Chronic Hypervitaminosis A
作者： Emanuel Rubin
DOI: 10.1001/ARCHPEDI.1970.02100050134008
关键词:
摘要: A 6-year-old girl who suffered from chronic hypervitaminosis developed hepato-splenomegaly, hepatic dysfunction, and hypersplenism. liver biopsy specimen displayed large lipid laden Kupffer's cells which were shown to contain vitamin by fluorescence microscopy. Electron microscopically injury was indicated increased lysosomes, focal cytoplasmic degradation, numerous "light" "dark" cells. These nonspecific indications of cell damage may reflect intracellular release the biologically active alcohol A.
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