Multiresidue determination of 11 new fungicides in grapes and wines by liquid–liquid extraction/clean-up and programmable temperature vaporization injection with analyte protectants/gas chromatography/ion trap mass spectrometry

摘要: Abstract A gas chromatographic ion trap mass spectrometry (GC-ITMS) method was developed for the determination of 11 new generation fungicides (benalaxyl, benalaxyl-M, boscalid, cyazofamid, famoxadone, fenamidone, fluquinconazole, iprovalicarb, pyraclostrobin, trifloxystrobin and zoxamide) in grapes wines. Samples were extracted with ethyl acetate:hexane (1:1, v/v) cleaned-up graphitized carbon black/primary secondary amine (GCB/PSA) solid-phase extraction (SPE) cartridges using acetonitrile:toluene (3:1, as eluent. The addition analyte protectants (3-ethoxy-1,2-propanediol, d -sorbitol l -gulonic acid γ-lactone) final extracts allowed to avoid matrix-induced response enhancement effect on quantitation process absolute recoveries ca. 100%. Precision (expressed relative standard deviation) lower than 16% all fungicides. Limits detection 0.01 mg/kg or mg/L, except much smaller cases maximum residue levels (MRLs) established by European Union Switzerland Italy proposed applied determine fungicide residues three different white vinification produced Ribeiro area Galicia (NW Spain), well their corresponding