The bone mineralization density distribution as a fingerprint of the mineralization process.

摘要: The inhomogeneous mineral content and its topographical distribution on a microscopic scale are major determinants of the mechanical quality trabecular bone. kinetics bone tissue deposition resorption together with mineralization process determine in tissue. heterogeneity is described by well-established density (BMDD), which experimentally accessible, e.g., using quantitative electron backscattering imaging (qBEI). In present work, we demonstrate that shape BMDD histogram reflects directly kinetics. Based experimental data from healthy human adults mathematical model for remodeling process, following main results were obtained. peaked necessarily two-phase fast primary phase slow secondary where corresponding time constants differ three orders magnitude. obtained law, describes increase packet as function time, provides information not only about initial surge, but also afterwards years. addition to turnover rate has strong influence peak position BMDD. theoretical framework opens new possibilities an analysis measured BMDDs respect changes caused diseases or treatments. It allows addressing whether have be attributed variation consequently affects disorder most likely reflecting alterations organic matrix. This important clinical interest because it helps find therapeutic approaches targeting etiological defects correct patients' towards normal