Enhancing dopamine treatments: worth the effort?

摘要: SUMMARY Dopamine-based treatments underlie our current management of the motor symptoms Parkinson’s disease. In this article, we look at development levodopa therapy, combination therapies with levodopa/dopa decarboxylase inhibitors, use dopamine agonists, monoamine oxidase catechol-O-methyl transferase inhibitors and nonoral delivery methods, in particular treatment complications later PD. There are some shortcomings dopamine-based including a limited benefit on non-motor manifestations We conclude by looking themes for future developments to further enhance methods.