Pathophysiology and laboratory findings in measles

摘要: Measles is a highly contagious disease characterized by prodromal illness of fever, coryza, cough, and conjunctivitis followed the appearance generalized maculopapular rash. Despite availability an effective safe live attenuated vaccine, measles remains cause continuing outbreaks in Japan. often accompanies diverse complications, including pneumonitis, otitis media, central nervous system involvement. Neurological complications includes ADEM, MIBE, SSPE. MIBE SSPE have unfavorable prognosis, which are caused persistent infection particular mutants virus (MV) brain. In patients, antibody titer increase cerebrospinal fluid serum. Primary vaccine failure secondary may be major Japan, therefore, promotion vaccination should emphasized. 2 doses methods began Japan 2006, supplementary program at 12 18 years old begins from 2008. Protection level varies according to measurement methods. NT provides best correlate for protection infection, however, needs complicated procedure. PA chosen surveillance method 1:128 or over seems level. To protect health-care associated MV, all health care worker under 35 vaccinated if not adequate immunity.