Immunity to Measles in Pregnant Mothers and in Cord Blood of Their Infants: Impact of HIV Status and Mother’s Place of Birth
作者： Shahana A. Choudhury , Frank Hatcher , Vladimir Berthaud , Gwinnett Ladson , Edward Hills
DOI: 10.1016/S0027-9684(15)31545-5
关键词: Immunology 、 Gestation 、 Medicine 、 Passive immunity 、 Pregnancy 、 Vaccination 、 Cord blood 、 Booster dose 、 Obstetrics 、 Umbilical cord 、 Measles
摘要: Antibody levels to measles were evaluated in 16 HIV-seropositive and 34 seronegative pregnant women cord blood samples of their infants. Infants followed prospectively, a second sample was taken at 3-7 months age. significantly lower HIV-exposed bloods birth (p=0.01 0.04, respectively) compared controls. The prevalence protective immunity (≥ 1.09 optical density ratio) also (p=0.02) women. T-cell counts who nonimmune (268/mm3) those immune (618/mm3), but the difference did not reach significance (p=0.07). Immunity declined nonprotective all infant obtained A secondary analysis determined impact mother’s place birth. higher (p=0.03) foreign-born HIV-seronegative (p=0.01) U.S.-born seen our inner-city clinic. Thus, even some may need booster vaccine ensure passage adequate passive immunity.
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