Pharmacokinetics of slow-release diltiazem and its effect on atrioventricular conduction in healthy volunteers.

作者: A. Gordin , P. Pohto , S. Sundberg , S. Nyk�nen , H. Haataja

DOI: 10.1007/BF00613518

关键词:

摘要: The pharmacokinetics and effect of a slow-release conventional diltiazem tablet on atrioventricular conduction were compared in randomized cross-over study after single dose at steady state 12 healthy volunteers.

参考文章(12)
J. Meier, E. N�esch, R. Schmidt, Pharmacokinetic criteria for the evaluation of retard formulations. European Journal of Clinical Pharmacology. ,vol. 7, pp. 429- 432 ,(1974) , 10.1007/BF00560355
K. Aoki, K. Sato, S. Kondo, M. Yamamoto, Hypotensive effects of diltiazem to normals and essential hypertensives. European Journal of Clinical Pharmacology. ,vol. 25, pp. 475- 480 ,(1983) , 10.1007/BF00542114
H. R. Ochs, M. Knüchel, Pharmacokinetics and absolute bioavailability of diltiazem in humans. Journal of Molecular Medicine. ,vol. 62, pp. 303- 306 ,(1984) , 10.1007/BF01716446
EVLIN L. KINNEY, RALPH M. MOSKOWITZ, ROBERT ZELIS, The pharmacokinetics and pharmacology of oral diltiazem in normal volunteers. The Journal of Clinical Pharmacology. ,vol. 21, pp. 337- 342 ,(1981) , 10.1002/J.1552-4604.1981.TB01778.X
Ph. Hermann, S. D. Rodger, G. Remones, J. P. Thenot, D. R. London, P. L. Morselli, Pharmacokinetics of diltiazem after intravenous and oral administration. European Journal of Clinical Pharmacology. ,vol. 24, pp. 349- 352 ,(1983) , 10.1007/BF00610053
William E. Strauss, Kevin M. McIntyre, Alfred F. Parisi, William Shapiro, Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: Report of a cooperative clinical trial The American Journal of Cardiology. ,vol. 49, pp. 560- 566 ,(1982) , 10.1016/S0002-9149(82)80012-X
Robert F. Zelis, Evlin L. Kinney, The pharmacokinetics of diltiazem in healthy American men The American Journal of Cardiology. ,vol. 49, pp. 529- 532 ,(1982) , 10.1016/S0002-9149(82)80007-6
Mark S. Smith, Chacko P. Verghese, David G. Shand, Edward L.C. Pritchett, Pharmacokinetic and pharmacodynamic effects of diltiazem. American Journal of Cardiology. ,vol. 51, pp. 1369- 1374 ,(1983) , 10.1016/0002-9149(83)90314-4