Pharmacokinetics of diltiazem after intravenous and oral administration.

摘要: The kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 administration. After i.v. administration biphasic elimination observed, with distribution half-life 0.3±0.2 h an 3.1±1.0 h; the apparent volume 5.3±1.71/kg total clearance 1.28±0.48 l/kg/h. dose phase had 3.2±1.3 h. absolute bioavailability diltiazem ranged from 24 to 74% (mean 42±18%). interindividual variation may be explained by variable first pass effect.