N-methyl-D-aspartate receptor activation and Ca2+ account for poor pyramidal cell structure in hippocampal slices.
作者： Sherry Feig , Peter Lipton
DOI: 10.1111/J.1471-4159.1990.TB04160.X
关键词:
摘要: The CA1 pyramidal cells appear damaged in micrographs of guinea pig hippocampal slices incubated normal physiological buffer at 36-37 degrees C. This is remedied if are modified buffers for the first 45 min. Cell morphology improved this devoid added Ca2+ and much it contains N-methyl-D-aspartate (NMDA) receptor antagonists or 0 mM 10 Mg2+. then similar to situ. These findings support notion that NMDA activation Ca2+, acting period immediately after slice preparation, permanently damage vitro.
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