Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IκBα-NF-κB signaling pathway
作者： Shu-Ting Lin , Ying Wang , Yang Xue , De-Chun Feng , Yan Xu
DOI: 10.1007/S11010-008-9787-4
关键词:
摘要: Astrocyte activation has been implicated in the pathogenesis of many neurological diseases. These reactive astrocytes are capable producing a variety proinflammatory mediators and potentially neurotoxic compounds, such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) interleukin-1beta (IL-1beta). In this study, we examined suppressive effects Tetrandrine (TET) on astrocyte induced by lipopolysaccharide (LPS) vitro. We found that TET decreased release NO, TNF-alpha, IL-6 IL-1beta LPS-activated astrocytes. Also mRNA expression levels inducible synthase (iNOS), macrophage inflammatory protein-1alpha (MIP-1alpha) vascular cell adhesion molecule-1 (VCAM-1) were inhibited pretreated Such might be resulted from inhibition nuclear factor kappa B (NF-kappaB) through downregulating IkappaB kinases (IKKs) phosphoration, which inhibitor factor-kappaB-alpha (IkappaBalpha) phosphoration degradation. Our results suggest acted to regulate inhibiting IKKs-IkappaBalpha-NF-kappaB signaling pathway.
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sci-hub.se 参考文章(37)
Young-Ji Shiao, Yun-Lian Lin, Ya-Hui Sun, Chih-Wen Chi, Chieh-Fu Chen, Chuen-Neu Wang, None, Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes. British Journal of Pharmacology. ,vol. 144, pp. 42- 51 ,(2005) , 10.1038/SJ.BJP.0706022
Narayan R. Bhat, Peisheng Zhang, John C. Lee, Edward L. Hogan, Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures The Journal of Neuroscience. ,vol. 18, pp. 1633- 1641 ,(1998) , 10.1523/JNEUROSCI.18-05-01633.1998
Ehab E. Tuppo, Hugo R. Arias, The role of inflammation in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. ,vol. 37, pp. 289- 305 ,(2005) , 10.1016/J.BIOCEL.2004.07.009
L. -l. Sun, C. Cheng, H. -o. Liu, C. -c. Shen, F. Xiao, J. Qin, J. -l. Yang, A. -g. Shen, Src suppressed C kinase substrate regulates the lipopolysaccharide-induced TNF-α biosynthesis in rat astrocytes Journal of Molecular Neuroscience. ,vol. 32, pp. 16- 24 ,(2007) , 10.1007/S12031-007-0003-X
Sankar Ghosh, Michael Karin, Missing Pieces in the NF-κB Puzzle Cell. ,vol. 109, pp. S81- S96 ,(2002) , 10.1016/S0092-8674(02)00703-1
Andrea Volterra, Jacopo Meldolesi, Astrocytes, from brain glue to communication elements: the revolution continues Nature Reviews Neuroscience. ,vol. 6, pp. 626- 640 ,(2005) , 10.1038/NRN1722
Nicholas J Maragakis, Jeffrey D Rothstein, Mechanisms of Disease: astrocytes in neurodegenerative disease Nature Reviews Neurology. ,vol. 2, pp. 679- 689 ,(2006) , 10.1038/NCPNEURO0355
Paul N. Moynagh, The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain Journal of Anatomy. ,vol. 207, pp. 265- 269 ,(2005) , 10.1111/J.1469-7580.2005.00445.X
Yang XUE, Ying WANG, De-chun FENG, Bao-guo XIAO, Ling-yun XU, Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway Acta Pharmacologica Sinica. ,vol. 29, pp. 245- 251 ,(2008) , 10.1111/J.1745-7254.2008.00734.X
Elena Ambrosini, Francesca Aloisi, Chemokines and Glial Cells: A Complex Network in the Central Nervous System Neurochemical Research. ,vol. 29, pp. 1017- 1038 ,(2004) , 10.1023/B:NERE.0000021246.96864.89