[33] Adenosine deaminase

摘要: Publisher Summary Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An deficiency observed cases of severe congenital immunodeficiency represents the first link between an immunological enzymic defect. from calf intestinal mucosa, most widely studied enzyme, hydrolytically deaminates, addition to adenosine, other natural synthetic nucleosides also dehalogenates 6-halopurine ribosides. Many studies have been carried out define contribution purine ribose moieties binding substrate help prepare effective inhibitors enzyme. chapter examines synthesis 9-(p-Bromoacetamidobenzyl) adenine, inactivation enzyme stoichiometry reaction, identification alkylated amino acid residues, kinetics reaction.