Environmental assessment of recombinant DNA fermentations

摘要: This issue of theJournal Industrial Microbiology contains a compilation papers presented at the 1992 National Meeting Society for in two symposia entitled ‘Environmental Assessment Recombinant DNA Fermentations’. It focuses on three areas particular interest to industry usingEscherichia coli K-12 strains make recombinant proteins: (i) current regulatory environment; (ii) plant design; (iii) results from five different companies all whom are using or planning use recombinantE. commercial fermentations. The pursuing questions environmental fate and potential gene transfer studies reached same conclusions. That is, their plasmidless hosts were unable survive any microcosm tested. Additionally, there was absolutely no evidence despite highly sensitive techniques measure such an event. seems reasonable conclude thatE. with recombinant, non-conjugating, poorly mobilizable plasmids do not represent hazards event accidental release microorganisms into environment.