Timed pulsatile drug delivery systems

摘要: A pharmaceutical dosage form such as a capsule capable of delivering therapeutic agents into the body in time-controlled or position-controlled pulsatile release fashion, is composed multitude multicoated particulates (beads, pellets, granules, etc.) made one more populations beads. Each these beads except an immediate bead has at least two coated membrane barriers. One barriers enteric polymer while second barrier mixture water insoluble and polymer. The composition thickness polymeric determine lag time duration drug from each populations. Optionally, organic acid containing intermediate may be applied for further modifying and/or release. delivery comprise pulses to provide plasma concentration-time profile agent, predicted based on both its pharmaco-kinetic pharmaco-dynamic considerations vitro/in vivo correlations.