Free radical modification of low-density lipoprotein: mechanisms and biological consequences.

作者: Jay W. Heinecke

DOI: 10.1016/0891-5849(87)90040-2

关键词:

摘要: Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells culture. In this review, free radical mechanisms the consequences modification are discussed.

参考文章(50)
Arthur E. Martell, Richard Gustafson, Stanley Chaberek, 33 Metal Chelate Compounds in Homogeneous Aqueous Catalysis Advances in Catalysis. ,vol. 9, pp. 319- 329 ,(1957) , 10.1016/S0360-0564(08)60181-9
E R Stadtman, S G Rhee, K Kim, Nonenzymatic cleavage of proteins by reactive oxygen species generated by dithiothreitol and iron. Journal of Biological Chemistry. ,vol. 260, pp. 15394- 15397 ,(1985) , 10.1016/S0021-9258(17)36264-6
E Graf, J R Mahoney, R G Bryant, J W Eaton, Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. Journal of Biological Chemistry. ,vol. 259, pp. 3620- 3624 ,(1984) , 10.1016/S0021-9258(17)43139-5
Martha K. Cathcart, Diane W. Morel, Guy M. Chisolm, Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. Journal of Leukocyte Biology. ,vol. 38, pp. 341- 350 ,(1985) , 10.1002/JLB.38.2.341
Diana M. Lee, Malondialdehyde formation in stored plasma Biochemical and Biophysical Research Communications. ,vol. 95, pp. 1663- 1672 ,(1980) , 10.1016/S0006-291X(80)80090-8
Don Carpenter, Vitamin E Deficiency Seminars in Neurology. ,vol. 5, pp. 283- 287 ,(1985) , 10.1055/S-2008-1064437
Victor W.M. van Hinsbergh, Mariëlle Scheffer, Louis Havekes, Herman Jan M. Kempen, Role of endothelial cells and their products in the modification of low-density lipoproteins. Biochimica et Biophysica Acta. ,vol. 878, pp. 49- 64 ,(1986) , 10.1016/0005-2760(86)90343-7
U. P. Steinbrecher, S. Parthasarathy, D. S. Leake, J. L. Witztum, D. Steinberg, Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 3883- 3887 ,(1984) , 10.1073/PNAS.81.12.3883