Periosteum-derived micro-grafts for tissue regeneration of human maxillary bone

摘要: The bone regeneration is one of the most important challenges for regenerative medicine. In maxillo-facial area, resorption alveolar crest occurs after tooth extraction and leads to several risks rehabilitation treatments, including dental implants procedures. Goal our study was demonstrate efficacy an innovative clinical protocol tissue engineering called Rigenera protocol, aimed create optimize bio-complexes constituted by collagen biomaterial human autologous periosteum-derived micro-grafts. We assessed capacity these prevent in with respect simple performing histological evaluations neo-formed osseous tissue. demonstrated that significantly reduced both horizontal vertical dimension when compared alone. also showed accelerate ossification process triggering formation new 45 days from treatment increasing calcified matrix 60 until 120 Taken together, data composed micro-grafts ridge preservation through a reduction enhancement formation.