The role of microorganisms in atopic dermatitis.

摘要: Atopic dermatitis (AD) is a common, fluctuating skin disease that often associated with atopic conditions such as asthma and IgE-mediated food allergy whose lesions are characterized by Th-2 cell-mediated response to environmental antigens. The increasing prevalence severity of diseases including AD over the last three decades has been attributed decreased exposure microorganisms during early life, which may result in an altered Th-1/Th-2-balance and/or reduced T cell regulation immune response. Patients exhibit defects innate acquired responses resulting heightened susceptibility bacterial, fungal viral infections, most notably colonization S. aureus. Toxins produced aureus exacerbate activity both induction toxin-specific IgE activation various types cells, eosinophils keratinocytes. Allergens expressed yeast Malazessia furfur, component normal flora, have also implicated pathogenesis subset patients. Microorganisms play influential role pathogenesis, interacting genes cause initiation exacerbation activity.