The potential role of kynurenines in Alzheimer’s disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors

摘要: The pathomechanism of neurodegenerative disorders still poses a challenge to neuroscientists, and continuous research is under way with the aim attaining an understanding exact background these devastating diseases. Alzheimer’s disease (AD) associated characteristic neuropathological features such as extracellular amyloid-β intracellular tau deposition. Glutamate excitotoxicity neuroinflammation are also factors that known contribute process, but cerebrovascular dysfunction has recently been implicated in AD. Current therapeutic tools offer moderate symptomatic treatment, fail reduce progression. kynurenine pathway (KP) development processes, alterations KP have demonstrated both acute chronic neurological disorders. Kynurenines suggested be involved regulation neurotransmission immunological processes. Targeting KP, therefore, offers valuable strategic option for attenuation glutamatergic excitotoxicity, neuroprotection.