An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase-Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases.
作者： Li Bo , Tan Guojun , Guo Li
关键词:
摘要: Many neurologic diseases are related to autoimmune dysfunction and a variety of molecules or reaction pathways involved in the regulation immune function nervous system. Soluble CD83 (sCD83) is soluble form CD83, specific marker mature dendritic cell, which has recently been shown have an immunomodulatory effect. Indoleamine 2,3-dioxygenase (IDO; corresponding enzyme intrahepatic, tryptophan 2,3-dioxygenase, TDO), rate-limiting extrahepatic kynurenine pathway (KP) participates immunoregulation through mechanisms solely with synergy sCD83, imbalances metabolites KP were associated dysfunction. With complement sCD83 IDO-KP, previously known axis, this review focused on expanded neuroimmunomodulation axis: sCD83-IDO-KP its involvement system diseases.
frontiersin.org
sci-hub.se 参考文章(191)
B. Widner, F. Leblhuber, D. Fuchs, Increased neopterin production and tryptophan degradation in advanced Parkinson's disease Journal of Neural Transmission. ,vol. 109, pp. 181- 189 ,(2002) , 10.1007/S007020200014
Erik Kwidzinski, Jörg Bunse, Adam D. Kovac, Oliver Ullrich, Frauke Zipps, Robert Nitsch, Ingo Bechmann, IDO (indolamine 2,3-dioxygenase) expression and function in the CNS. Advances in Experimental Medicine and Biology. ,vol. 527, pp. 113- 118 ,(2003) , 10.1007/978-1-4615-0135-0_13
Gayan Jayawickrama, Richard Sadig, Guanchen Sun, Alireza Nematollahi, Naveed Nadvi, Jane Hanrahan, Mark Gorrell, W. Church, Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia. Current Medicinal Chemistry. ,vol. 22, pp. 2902- 2918 ,(2015) , 10.2174/0929867322666150608094054
Ildikó Demeter, Károly Nagy, Levente Gellért, László Vécsei, Ferenc Fülöp, József Toldi, None, A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study: Special issue related to Kynurenine Journal of Neural Transmission. ,vol. 119, pp. 151- 154 ,(2012) , 10.1007/S00702-011-0755-X
Gislaine Z. Réus, Karen Jansen, Stephanie Titus, André F. Carvalho, Vilma Gabbay, João Quevedo, Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies. Journal of Psychiatric Research. ,vol. 68, pp. 316- 328 ,(2015) , 10.1016/J.JPSYCHIRES.2015.05.007
Melissa Cavalheiro Tourino, Edson Mendes de Oliveira, Luziane Potrich Bellé, Franciele Hinterholz Knebel, Renata Chaves Albuquerque, Felipe Augusto Dörr, Sabrina Sayori Okada, Silene Migliorini, Irene Silva Soares, Ana Campa, Tryptamine and dimethyltryptamine inhibit indoleamine 2, 3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells Cell Biochemistry and Function. ,vol. 31, pp. 361- 364 ,(2013) , 10.1002/CBF.2980
Aye M. Myint, Kynurenines: from the perspective of major psychiatric disorders. FEBS Journal. ,vol. 279, pp. 1375- 1385 ,(2012) , 10.1111/J.1742-4658.2012.08551.X
Gregory F. Oxenkrug, Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism Annals of the New York Academy of Sciences. ,vol. 1199, pp. 1- 14 ,(2010) , 10.1111/J.1749-6632.2009.05356.X
Yiquan Chen, Gilles J. Guillemin, Kynurenine Pathway Metabolites in Humans: Disease and Healthy States: International Journal of Tryptophan Research. ,vol. 2, pp. 1- 19 ,(2009) , 10.4137/IJTR.S2097
K M Hargreaves, W M Pardridge, Neutral amino acid transport at the human blood-brain barrier. Journal of Biological Chemistry. ,vol. 263, pp. 19392- 19397 ,(1988) , 10.1016/S0021-9258(19)77645-5