A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study: Special issue related to Kynurenine
作者： Ildikó Demeter , Károly Nagy , Levente Gellért , László Vécsei , Ferenc Fülöp
DOI: 10.1007/S00702-011-0755-X
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摘要: The concentration of kynurenic acid (KYNA) in the cerebrospinal fluid, which is nanomolar range, known to decrease epilepsy. experimental data suggest that treatment with L: -KYN dose dependently increases neuroprotective KYNA brain, itself hardly crosses blood-brain barrier. However, it suggested new synthetic analogs may readily cross In this study, we tested hypothesis a analog administered systemically sufficient results decreased population spike activity recorded from pyramidal layer area CA1 hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures.
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