作者: Ramona R. Hicks , Douglas H. Smith , Thomas A. Gennarelli , Tracy McIntosh
DOI: 10.1016/0006-8993(94)91601-2
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摘要: Pharmacologic inhibition of excitatory amino acid neurotransmission improves physiologic, metabolic, and neurobehavioral outcome following experimental brain trauma. However, no studies to date have demonstrated pharmacologically-induced attenuation histopathological changes associated with injury models. The present study examined the effects kynurenate, an NMDA non-NMDA receptor antagonist, on neuronal survival in hippocampus after lateral fluid-percussion rat. Animals (n = 10/treatment) randomly received intravenous injection either kynurenate (300 mg/kg) or buffer (equal volume) 15 min moderate severity. Two weeks injury, animals were sacrificed cell loss was Nissl staining. Selective neurons CA3 region hippocampus, which has previously been characterized this model found be significantly attenuated treatment (P < 0.05). These data suggest that pharmacologic compounds are known beneficial physiological may also attenuate post-traumatic loss. Our results support other recent pharmacological intervention antagonist therapeutic value injury.