Streptococcus pyogenes infects human endometrium by limiting its immune response

摘要: Abstract Group A Streptococcus (GAS), a Gram-positive human-specific pathogen yields 517,000 deaths annually worldwide, including 163,000 due to invasive infections and among them puerperal fever. GAS is their most feared etiologic agent. Puerperal fever still accounts for more than 75,000 maternal before the introduction of efficient prophylactic measures 10% childbirths were followed by mother’s death. Yet little known regarding infection establishment or efficiency in causing postpartum infection. To characterize its early steps, we set up coordinated analyses ex vivo human decidua, portal entry. We analyzed behavior immune response triggered. demonstrate that (i) benefits from tissue secreted products multiply; (ii) invades leads death half cells within two hours via SpeB protease Streptolysin O activities, respectively; (iii) impairs response. Immune impairment occurs both at RNA level, with induction only restricted immediate innate response, protein SLO- SpeB-dependent manner. Our study indicates decidua invasion restraint favor propensity develop rapid gynecological-obstetrical context.