Towards a re-emergence of chloroquine sensitivity in Côte d'Ivoire?
作者： Oléfongo Dagnogo , Aristide Berenger Ako , Lacinan Ouattara , Noel Dougba Dago , David N’golo Coulibaly
DOI: 10.1186/S12936-018-2551-7
关键词:
摘要: Resistance of Plasmodium falciparum to anti-malarial drugs has hampered efforts eradicate malaria. Recent reports a decline in the prevalence chloroquine-resistant P. several countries, including Malawi and Zambia, is raising hope reintroducing chloroquine near future, ideally combination with another drug for treatment uncomplicated In Cote d’Ivoire, decrease clinical efficacy chloroquine, addition high proportion isolates carrying Thr-76 mutant allele pfcrt gene, had led discontinuation use 2004. Previous studies have indicated persistence despite withdrawal as first-line drug. This present study conducted determine Thr-76T Pfcrt gene after decade ban on sale d’Ivoire. Analysis 64 sequences from all three sites 15% (10/64) against 62% (40/64) Lys-76 wild-type allele. No mutation was observed at Anonkoua Koute while this 31% (5/16) 25% (5/20) isolate Port-Bouet Ayame respectively. More than parasites sensitive seems increase Anonkoua-koute, Port-bouet Ayame.
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