Metal ion transport in eukaryotic microorganisms: insights from Saccharomyces cerevisiae.

摘要: Metal ions such as iron, copper, manganese, and zinc are essential nutrients for all eukaryotic microorganisms. Therefore, these organisms possess efficient uptake mechanisms to obtain from their extracellular environment. must also be transported into intracellular organelles where they function catalytic structural cofactors compartmentalized enzymes. Thus, transport present. When present in high levels, metal can toxic, so is tightly regulated at both transcriptional post-transcriptional levels limit ion overaccumulation facilitate storage sequestration. Remarkable molecular insight processes has come recent studies of the yeast Saccharomyces cerevisiae. This organism, which primary subject this chapter, serves a useful paradigm understand metabolism other microbes.