Saccharomyces cerevisiae as Biosensor for Cyto- and Genotoxic Activity
作者： Jost Ludwig , Marcel Schmitt , Hella Lichtenberg-Fraté
DOI: 10.1007/978-1-4020-9674-7_17
关键词:
摘要: Conventionally, toxicological bioassays are based on rodent models to evaluate the toxic effects of chemical compounds and study mechanism action toxicants. However, scientific developments required keep in line with regulatory frameworks, such as existing EU guidelines for assessment manufactured chemicals (67/548/EEC, 93/67/EEC, 83/571/EEC) framework (REACH, EC1907/2006) concerning part also chemicals. Scientific thus directed towards rapid reliable highthroughput assays more accurately mechanistically potential hazards large numbers The yeast Saccharomyces cerevisiae is a promising model because it amenable genetic studies vast amount genomics knowledge, resources, manipulative tools associated this unicellular fungus. high degree homology essential cellular organization metabolism shared by S. higher eukaryotes has enabled aspects toxicity phenomena relevance human biology at molecular level.
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