Differential gene expression in diabetic nephropathy in individuals with type 1 diabetes
作者： M. Luiza Caramori , Youngki Kim , Allison B. Goldfine , Jason H. Moore , Stephen S. Rich
DOI: 10.1210/JC.2014-4465
关键词:
摘要: Context: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) in United States. Objective: The aim this study was to determine whether there were skin fibroblast gene expression differences between subjects with type 1 diabetes (T1D) or without DN. Setting: This a cross-sectional conducted University Minnesota. Patients: Study volunteers 100 former participants Genetics Kidneys Diabetes: 40 diabetic Controls, normoalbuminuric after ≥ 15 years T1D; and 60 DN Cases, 25 proteinuria 35 ESRD. Intervention(s): Skin fibroblasts grown high glucose (HG) for five passages (approximately 6 weeks). Main Outcome Measure(s): SF assessed by transcriptome sequencing using Illumina HiSeq 2000 platform. Pathway analyses tested directionally consistent group within Kyoto Encyclopedia Genes Genomes pathways. Results: Eight pathways, all related cell cy...
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sci-hub.se 参考文章(37)
W Fujibuchi, H Bono, H Ogata, S Goto, M Kanehisa, T Nishioka, K Sato, Organizing and computing metabolic pathway data in terms of binary relations. pacific symposium on biocomputing. pp. 175- 186 ,(1997)
A. J. Matas, J. M. Smith, M. A. Skeans, B. Thompson, S. K. Gustafson, D. E. Stewart, W. S. Cherikh, J. L. Wainright, G. Boyle, J. J. Snyder, A. K. Israni, B. L. Kasiske, OPTN/SRTR 2013 Annual Data Report: kidney. American Journal of Transplantation. ,vol. 15, pp. 1- 34 ,(2015) , 10.1111/AJT.13195
E. Iori, M. C. Marescotti, M. Vedovato, G. Ceolotto, A. Avogaro, A. Tiengo, S. Del Prato, R. Trevisan, In situ protein kinase C activity is increased in cultured fibroblasts from Type 1 diabetic patients with nephropathy Diabetologia. ,vol. 46, pp. 524- 530 ,(2003) , 10.1007/S00125-003-1061-4
Yaqin Tu, Zhi-Guang Zhou, Cai Chen, Junru Pan, Cong-Yi Wang, Junfa Xu, The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis. International Journal of Clinical and Experimental Pathology. ,vol. 5, pp. 726- 738 ,(2012)
Amparo Lurbe, Paola Fioretto, Michael Mauer, Michael S. LaPointe, Daniel Batlle, Growth phenotype of cultured skin fibroblasts from IDDM patients with and without nephropathy and overactivity of the Na+/H+ antiporter. Kidney International. ,vol. 50, pp. 1684- 1693 ,(1996) , 10.1038/KI.1996.486
David Reif, Jason Moore, Visual analysis of statistical results from microarray studies of human breast cancer. decision support systems. ,vol. 15, pp. 1043- 1047 ,(2006) , 10.3892/OR.15.4.1043
Martin Siczkowski, Joan E. Davies, Frank P. Sweeney, Allan Kofoed-Enevoldsen, Leong L. Ng, Na+/H+ exchanger isoform-1 abundance in skin fibroblasts of type I diabetic patients with nephropathy Metabolism-clinical and Experimental. ,vol. 44, pp. 791- 795 ,(1995) , 10.1016/0026-0495(95)90194-9
Zhongwei Li, Jinhua Wu, Christopher DeLeo, RNA Damage and Surveillance under Oxidative Stress Iubmb Life. ,vol. 58, pp. 581- 588 ,(2006) , 10.1080/15216540600946456
Nicholette D. Palmer, Barry I. Freedman, Insights into the Genetic Architecture of Diabetic Nephropathy Current Diabetes Reports. ,vol. 12, pp. 423- 431 ,(2012) , 10.1007/S11892-012-0279-2
DAVID M. REIF, SCOTT M. DUDEK, CHRISTIAN M. SHAFFER, JANEY WANG, JASON H. MOORE, Exploratory visual analysis of pharmacogenomic results. pacific symposium on biocomputing. pp. 296- 307 ,(2004) , 10.1142/9789812702456_0028