Modification of serum luteinizing hormone and prolactin concentrations by corticotropin and adrenalectomy in ovariectomized rats.

摘要: The effects of ACTH and adrenalectomy (ADX) on serum concentrations luteinizing hormone (LH) prolactin were examined in ovariectomized (OVZ) rats. In the 1st study (4 IU) was adminstered daily for 1 week. prevented an increase LH response to OVX stimulated prolactin. also reduced + ADX rats increased concentration. utilized 2nd experiment enhance secretion endogenous ACTH. 2 weeks after elevated above intact values. enhanced level found animals. markedly but alone without effect All these findings indicate that acts directly reduce concentration influence adrenal corticoids as reported by other investigators appears be mediated via their negative feedback release. Whether has its action adenohypoplyseal cells or hypothalamic sites yet determined.(Authors modified)