Perinatal ACTH-naloxone treatment: Effects on physical and behavioral development☆

摘要: Abstract Pregnant mice were treated with either ACTH or naloxone, both, from 2 to 5 days prior parturition, until postpartum. Perinatal caused a retardation of growth, eye opening, and vaginal opening that was blocked by naloxone; perinatal naloxone produced decrease in open field activity at 32 age ACTH; reduced the threshold for heat 50 no interaction treatment. It is proposed part role physical systems may be mediated via naloxone-sensitive receptors. The direct effect on another class receptors mediate changes flinch. Effects mother have indirectly alterations motor development offspring.