Pre- and postnatally administered ACTH, Organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice

摘要: This study investigated the effect of learning/memory-related neuropeptides on behavioral task performance in later life. A 1 mg/kg dosage adrenocorticotropic hormone 4-9, Organon 2766, ACTH/MSH 4-10, ACTH 1-24, CRF, or diluent was subcutaneously injected into either pregnant females newborn pups during specific neural developmental windows. Each progeny trained an active-avoidance and tested for acquisition postpartum days 35-37. The mice were then memory reacquisition 42-44 using identical experimental paradigm as that used training sessions. Prenatal treatment with these memory-related resulted significant facilitation learning/memory male female treated 2766 (p less than 0.001), a inhibition males 1-24 0.01). Additional sex-specific facilitations inhibitions from pre- postnatal administration various this study. These results suggest neuropeptides, when available increased amounts windows, can significantly improve suppress related capability