Modulation of Presynaptic Store Calcium Induces Release of Glutamate and Postsynaptic Firing

摘要: Action potential-independent transmitter release is random and produces small depolarizations in the postsynaptic neuron. This process is, therefore, not thought to play a significant role impulse propagation across synapses. Here we show that calcium flux through presynaptic neuronal nicotinic receptors leads mobilization of store by calcium-induced release. Recruitment induces vesicular glutamate manner consistent with synchronization multiple active zones CA3 region rat hippocampus. modulation action sufficient drive pyramidal cell above its firing threshold, thus providing mechanism for propagation.